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Despite numerous lofty predictions from analysts and market watchers, 2011 wasn?t the year of the tablet. Not by a long shot. Apple?s iPad 2 continued to sell well this past year but among dozens of rivals, only a handful of tablets managed to garner even the slightest interest from consumers. No, 2011 was the year of the smartphone. Global smartphone penetration is now approaching 10% and in the United States, nearly half of all cell phone users own smartphones. While smartphones proliferated all year long, 2011 would save the best for last: at the start of the fourth quarter, Apple launched its latest iPhone handset and as the year drew to a close, Verizon and?Samsung released the Galaxy Nexus.

The frequency and breadth of rumors leading up to Apple?s next-generation iPhone announcement?was astounding in 2011. Some reports suggested the next iPhone would be a modest bump compared to the iPhone 4 while others said it would be a full-fledged redesign. A number of sites, including BGR, reported information from proven sources suggesting that the new iPhone would feature a larger display and a new case design. Even The New York Times was hearing rumblings of an all new iPhone design.?There were also a dozen reports suggesting an ?iPhone 4S? and an ?iPhone 5? would launch simultaneously.

Meanwhile Samsung and Google were quietly working on a next-generation flagship Nexus phone that would be the first smartphone to launch with Android 4.0 Ice Cream Sandwich on board. At least, the companies were quietly working on the handset until BGR issued a pair of exclusive reports exposing a number of details surrounding the new phone.

As summer heated up and a number of new smartphones were hitting the market, BGR learned that Google?s new flagship phone would launch as a Verizon Wireless exclusive in the U.S., and the carrier was looking to slap its renowned ?DROID? branding on the handset. October was the initial launch month set for the new pure Google device, and Verizon even passed on another popular Samsung phone to make room for the new Ice Cream Sandwich-powered phone. October was shaping up to be quite a month, as new information pointed to a mid-October launch for Apple?s next-generation iPhone as well.

October finally came, and Apple announced the iPhone 4S. With sky-high iPhone 5 expectations, however, not everyone was impressed with Apple?s new smartphone. It wasn?t until the smoke cleared that consumers?realized?Apple had another winner on its hands, and the new camera, faster chipset and Siri made the iPhone 4S a force to be reckoned with. Only one device might pose a real challenge to the new iPhone, and BGR exclusively revealed its full specs just days after the iPhone 4S was unveiled.

But alas, Samsung and Google announced that they were delaying the announcement of their new superphone for reasons that were never truly made clear. Apple would go on to sell more than 4 million iPhone 4S handsets during the device?s debut weekend alone, and the Galaxy Nexus was finally unveiled?a day after Apple revealed the staggering iPhone sales figures. There was still no word on when we could expect Verizon to finally launch the phone, however, and two more months would pass before the carrier?finally offered?Samsung?s Galaxy Nexus to subscribers for $300 on contract.

BGR reviewed the iPhone 4S and we were very impressed with Apple?s update. We were also blown away by the Galaxy Nexus, calling it our ?favorite Android device in the world? in our full review. Even after a month with each handset, the iPhone 4S and Galaxy Nexus remained our favorite smartphones of 2011. With the Consumer Electronics Show and Mobile World Congress just around the corner, Apple and Samsung?s flagship phones will undoubtedly see some solid contenders emerge. Whether or not they?ll be able to supplant these two phenomenal phones, however, remains to be seen.

Source: http://feedproxy.google.com/~r/TheBoyGeniusReport/~3/QDqgQ5fYxwY/

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Work on the National September 11 Memorial Museum has been halted over a budgetary dispute, making it impossible to open on time, New York City Mayor Michael Bloomberg said.
"There's no chance of it being open on time. Work has basically stopped," Bloomberg said during a press conference Thursday.
The museum was scheduled to open on the 11th anniversary of the September 11, 2001, terror attacks.
The Mayor blamed the holdup on "disagreements" with the Port Authority of New York and New Jersey, which is responsible for a portion of project's financing.

FULL STORY

Source: http://news.blogs.cnn.com/2011/12/30/no-chance-of-911-museum-opening-on-time-new-york-mayor-says/

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home > Management > Research on Competitive Strategy of Ericsson (China) Communications Co., Ltd. in China 3G Market

?Abstract? In the eighties, 20th century, Michael E. Porter, the professor at Harvard business school and the famous leading authority on competitive stategy, originated a point of view that the vital concern of the strategy for an enterprise is to face the competition. And then the three generic competitive strategies including cost leadership, differentiation, and focus became a common method for practice of coping with industry structure. With the changes of competition in different industries and the increase of uncertainty for enterprise operating environment, especially with the birth of new industries and the emergence of new forms of enterprises lead by innovation and reformation, the competitive strategy originated by Porter become to show some limitations in specific domains. The research on competitive strategy for foreign investment telecommunication equipment manufacturers is at the stage of exploiting and developing. Therefor, based on the fundamental of competitive analysis and competitive strategy, the thesis analyses both opportunities and challenges to Ericsson in China 3G market, and study competitive strategy from 2 aspects including positive responds to the changes of external competitive environment and enhancement of internal core competitiveness to establish enterprise advantage, and hope it will be useful to Ericsson to maintain its industry leadership and achieve long-term sustainable development in the fierce market competition. The thesis includes total 4 chapters. The first chapter invokes the subject of the thesis, and describes both theoretical and practical backgrounds, and research purpose, meaning, and method of the thesis. The second chapter depicts the fundamentals of competitive theory including valus chains, cost analysis, diamond model, industrial cluster, and its influence on enterprise competitiveness. Chapter 3 and 4 are the key sections of the thesis. The third chapter firstly introduces the brief of Ericsson and Ericsson (China) Communications Co., Ltd., and then analysis the impacts on the competitive environment of China 3G market with the developments of global telecommunications industry and industry policy in China, and indicates Ericsson should take a quick respond to the change of external competitive environment as well as shape the conductive competitive environment based on the the main profit source of its own. On the basis of analysis and study in the previous chapter, the fourth chapter focuses on the research of strengthen internal transformation and improve its core competitiveness, and proposes some constructive strategic suggestions to Ericsson (China) for the purpose of technical and marketing leading position as well as operatation excellence.

URL:http://www.economics-papers.com/research-on-competitive-strategy-of-ericsson-china-communications-co-ltd-in-china-3g-market.html
Title: Research on Competitive Strategy of Ericsson (China) Communications Co., Ltd. in China 3G Market
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New York ? A disappointing opening weekend at the box office jeopardizes the future of David Fincher's Hollywood adaptation of Stieg Larsson's Millennium trilogy

The Hollywood remake of The Girl With the Dragon Tattoo seemed to have all the trappings of a surefire hit. The book it's based on ? the first installment of Stieg Larsson's massively popular Millennium trilogy ? sold more than 17 million copies in the U.S., and already proved cinematically successful with 2009's well-received Swedish adaptation. Fincher is an Oscar-nominated director, and James Bond himself, Daniel Craig, is the American movie's star. Plus, there were rave reviews, loads of advance hype, and a starmaking turn from Rooney Mara as the punkish private investigator Lisbeth Salander. Yet thus far, the film has been a box office flop. It opened last weekend with just $13 million (compared to its $90 million budget), finishing in fourth place. What happened? Perhaps it was the glut of releases to compete with, the long running time, or the film's extremely dark material ? as Lisbeth helps a reporter (played by Craig) solve a harrowing murder case, she herself is brutally assaulted. But now, the disappointing box office puts the planned sequels to Dragon Tattoo, based on Larsson's The Girl Who Played With Fire and The Girl Who Kicked the Hornet's Nest, in jeopardy. Will they be scrapped?

It's not looking good: After the film's dismal opening in the U.S., the future of the franchise depends on how well it plays overseas, box-office analyst Jeff Bock tells MTV News. But international success is hardly a sure thing.?The Swedish version of Dragon Tattoo is barely two years old, and was a massive success around the world, grossing nearly $100 million. "Do overseas audiences really want to see the Hollywood version after the original is so fresh in their minds and was equally well-received?"
"Girl With the Dragon Tattoo: Why it didn't dominate"

Blame the perplexing foreign remake curse: Given the poor box office for Dragon Tattoo, sequels aren't likely, says Steven Zietchik at the Los Angeles Times. Maybe we should have expected this. "Many of Hollywood's star-driven follow-ups to foreign-language hits have been flops." Remember the war drama Brothers (a remake of a Danish film) and the vampire thriller Let Me In (based on the Swedish Let the Right One In)? The failure of the English version of Dragon Tattoo proves that "the idea of taking a compelling foreign story and giving it a Hollywood gloss doesn't work as well as backers might think."
"Dragon Tattoo: Why do so many foreign remakes struggle?"

Actually, the film still has time to succeed: Don't write off Dragon Tattoo quite yet, Nikki Finke, founder of Deadline.com, tells the New York?Daily News. The film has been plagued by an unwise release date ? this isn't exactly the heartwarming sort of film audiences are lining up to see over the Christmas holiday. But once Christmas is behind us, we get into the time of year that older audiences go to the movies, and "there isn't much out there for adults."?Plus, word of mouth is largely positive, hinting that the film could rebound and prove sequel-worthy.
"Girl With the Dragon Tattoo's low box ofice take leaves future of sequels a mystery"

View this article on TheWeek.com
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Source: http://twitter.com/LeilaSumma/statuses/149765644613722112

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PBR Staff Writer Published 23 December 2011

AVEO Pharmaceuticals has begun patient enrollment in Phase 2 clinical trial of tivozanib in combination with mFOLFOX6 in patients with advanced colorectal cancer.

The randomized trial, called BATON-CRC, will enroll approximately 252 patients with no prior VEGF-targeted therapy at approximately 80 centers in the US, Canada, Australia and Europe, the company said.

Patients will be randomized to one of the two treatments arms in a 2:1 ratio (168 patients in the tivozanib arm and 84 patients in the bevacizumab arm).

AVEO chief medical officer William Slichenmyer said the identification and development of relevant biomarkers through their human response platform is a core component of our oncology drug development efforts.

"We plan to use biomarker data from BATON-CRC and BATON-RCC to inform our clinical development strategy in an effort to bring tivozanib to patients who will benefit most," Slichenmyer added.

Source: http://clinicaltrials.pharmaceutical-business-review.com/news/aveo-initiates-phase-2-colorectal-cancer-trial-231211

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MORRIS TOWNSHIP, N.J. ? A small plane heading for Georgia spiraled out of control and crashed Tuesday morning on a major New York-area highway, hitting a wooded median and scattering wreckage across the road. All five people aboard, including two investment bankers, were killed, but no one on the ground was injured.

The pilot had discussed icy conditions with controllers just before the plane went down, but investigators were unsure what role, if any, icing played in the crash.

The New York investment banking firm Greenhill & Co. said two of its managing directors, Jeffrey Buckalew, 45, and Rakesh Chawla, 36, as well as Buckalew's wife and two children, were on the plane, which crashed on Interstate 287. Buckalew was the registered owner of the single-engine plane and had a pilot's license.

Wreckage was scattered over at least a half-mile, with a section found lodged in a tree of a home about a quarter-mile away, near a highway entrance ramp. The crash closed both sides of the busy highway for hours, though several lanes were open again in time for the evening rush hour.

National Transportation Safety Board investigators said the search for wreckage was suspended after dark Tuesday and would be resumed after the Wednesday morning commute to minimize traffic problems.

NTSB officials said they don't believe the plane had a black box, which would have recorded flight data, but they said investigators were searching for other memory devices, including GPS, collision avoidance systems or any device with a recordable chip that might yield more information.

Rockaway Township resident Chris Covello said he saw the plane spin out of control from the car dealership where he works in Morristown, near the site of the crash.

"It was like the plane was doing tricks or something, twirling and flipping," he said. "It started going straight down. I thought any second they were going to pull up. But then the wing came off and they went straight down."

The high-performance Socata TBM-700 turboprop had departed from nearby Teterboro Airport in New Jersey and crashed about 14 minutes into its flight. It was headed for DeKalb Peachtree Airport near Atlanta.

The pilot had a seven-second call with a controller about icing shortly before the crash, NTSB investigator Robert Gretz said.

Gretz said he did not know whether the pilot was reporting icing had occurred or was questioning the location of possible icing conditions. He said he was unaware of any icing on the ground that would have required deicing.

The Federal Aviation Administration said the pilot had requested clearance to a higher altitude shortly before the plane dropped off radar. The NTSB said the plane had climbed to 17,500 feet.

Ice can form on airplanes when temperatures are near freezing and there is visible moisture, such as clouds or rain. The ice adds weight to an aircraft, and rough accumulations known as rime interrupt the flow of air over wings.

In extreme cases, a plane can lose so much lift that it falls out of the sky.

Icing played a role in crashes in 2009 involving a Colgan Air flight outside Buffalo and an Air France flight off the coast of Brazil. In both cases the pilots sent their airplanes into uncontrolled spins while trying to deal with accumulations of ice. The Colgan plane crashed into a house.

Most versions of the TBM-700 have deicing systems. But recordings available online show that even airliners with powerful deicing equipment were having trouble clearing the ice Tuesday. The pilot of a commuter jetliner headed to nearby LaGuardia Airport in New York asked a controller for an immediate climb into drier conditions.

The pilot of the TBM-700 was told to maintain an altitude of 10,000 feet as he headed southwest over northern New Jersey. A controller warned him about the conditions in the clouds above.

"There are reports of moderate rime. ... If it gets worse let me know and when center takes your handoff I'll climb you and maybe get you higher," the controller said.

The pilot responded: "We'll let you know what happens when we get in there. And, yeah, if we could go straight through it, that's no problem for us."

Teenager David Williamson was doing maintenance at a golf course in Morristown when he spotted a plane in trouble, with smoke coming off both sides of the wings.

"It was really scary," he said.

When the plane crashed, he said, it sent up a "huge plume of thick black smoke."

The plane just missed a pickup truck on the southbound lanes before crashing into the median, Gretz said.

Charred wreckage was left across the median and highway, a heavily used route that wraps around the northern and western edges of the New York City area. A huge ball of charred metal sat in the middle of the northbound lanes.

The occupants of the plane were headed to Georgia for personal and business reasons, Gretz said.

Greenhill & Co. said Buckalew's wife, Corinne, and the couple's two children, Jackson and Meriwether, were traveling with him.

"The firm is in deep mourning over the tragic and untimely death of two of its esteemed colleagues and members of Jeff's family," the company said in a written statement.

A resident at Chawla's Manhattan apartment building remembered him as being constantly on the go, leaving early and getting home late. Arthur Yellin said that Chawla and his family were "wonderful people" and that the banker doted on his three children.

Authorities said a dog aboard the plane also was killed.

___

Contributing to this report were Associated Press writers Shawn Marsh and Beth DeFalco in Trenton, David Porter in Newark, Christopher Hawley and Cristian Salazar in New York, and Leonard Pallats in Atlanta.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111221/ap_on_re_us/us_plane_crash_highway

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Feature Articles | Health Cover Image: January 2012 Scientific American Magazine

See Inside

When Ralph M. Steinman developed pancreatic cancer, he put his own theories about cancer and the immune system to the test. They kept him alive longer than expected?but three days short of learning he had won the Nobel Prize

By Katherine Harmon ?| December 20, 2011

Image: Illustration by Roberto Parada

In Brief

Ralph M. Steinman was the first person to describe dendritic cells, which play a key role in initiating immune responses. He named them for their treelike limbs.

Dendritic cells, which ?teach? other immune cells what to attack, now make up the core of many experimental vaccines against cancer and HIV.

When Steinman was diagnosed with pancreatic cancer in 2007, he and a network of colleagues turned to these new vaccines to treat his disease.

His colleagues believe the vaccines helped to extend his life well beyond the norm. He died just three days before winning the Nobel Prize.

Peering through a microscope at a plate of cells one day, Ralph M. Steinman spied something no one had ever seen before. It was the early 1970s, and he was a researcher at the Rockefeller University on Manhattan?s Upper East Side. At the time, scientists were still piecing together the basic building blocks of the immune system. They had figured out that there are B cells, white blood cells that help to identify foreign invaders, and T cells, another type of white blood cell that attacks those invaders. What puzzled them, however, was what triggered those T cells and B cells to go to work in the first place. Steinman glimpsed what he thought might be the missing piece: strange, spindly-armed cells unlike any he had ever noticed.

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Friday, December 16, 2011

When a meteorite careens toward the dusty surface of the Red Planet, it kicks up dust and can cause avalanching even before the rock from outer space hits the ground, a research team led by an undergraduate student at the University of Arizona has discovered.

"We expected that some of the streaks of dust that we see on slopes are caused by seismic shaking during impact," said Kaylan Burleigh, who led the research project. "We were surprised to find that it rather looks like shockwaves in the air trigger the avalanches even before the impact."

Because of Mars' thin atmosphere, which is 100 times less dense than Earth's, even small rocks that would burn up or break up before they could hit the ground here on Earth crash into the Martian surface relatively unimpeded.

Each year, about 20 fresh craters between 1 and 50 meters (3 to 165 feet) show up in images taken by the HiRISE camera on board NASA's Mars Reconnaissance Orbiter. The High Resolution Imaging Science Experiment, or HiRISE, is operated by the UA's Lunar and Planetary Laboratory and has been photographing the Martian surface since 2006, revealing features down to less than 1 meter in size.

For this study, the team zoomed in on a cluster of five large craters, which all formed in one impact event close to Mars' equator, about 825 kilometers (512 miles) south of the boundary scarp of Olympus Mons, the tallest mountain in the solar system. Previous observations by the Mars Global Surveyor orbiter, which imaged Mars for nine years until 2006, showed that this cluster was blasted into the dusty surface between May 2004 and February 2006.

The results of the research, which Burleigh first took on as a freshman under former UA Regents Professor H. Jay Melosh, are published in the planetary science journal Icarus. Previous studies had looked at dark or light streaks on the Martian landscape interpreted as landslides, but none had tied such a large number of them to impacts.

The authors interpret the thousands of downhill-trending dark streaks on the flanks of ridges covering the area as dust avalanches caused by the impact. The largest crater in the cluster measures 22 meters, or 72 feet across and occupies roughly the area of a basketball court. Most likely, the cluster of craters formed as the meteorite broke up in the atmosphere, and the fragments hit the ground like a shotgun blast.

Narrow, relatively dark streaks varying from a few meters to about 50 meters in length scour the slopes around the impact site.

"The dark streaks represent the material exposed by the avalanches, as induced by the the airblast from the impact," Burleigh said. "I counted more than 100,000 avalanches and, after repeated counts and deleting duplicates, arrived at 64,948."

When Burleigh looked at the distribution of avalanches around the impact site, he realized their number decreased with distance in every direction, consistent with the idea that they were related to the impact event.

But it wasn't until he noticed a pair of peculiar surface features resembling a curved dagger, described as scimitars, extending from the central impact crater, that the way in which the impact caused the avalanches became evident.

"Those scimitars tipped us off that something other than seismic shaking must be causing the dust avalanches," Burleigh said.

As a meteor screams through the atmosphere at several times the speed of sound, it creates shockwaves in the air. Simulating the shockwaves generated by impacts on Martian soil with computer models, the team observed the exact pattern of scimitars they saw on their impact site.

"We think the interference among different pressure waves lifts up the dust and sets avalanches in motion. These interference regions, and the avalanches, occur in a reproducible pattern," Burleigh said. "We checked other impact sites and realized that when we see avalanches, we usually see two scimitars, not just one, and they both tend to be at a certain angle to each other. This pattern would be difficult to explain by seismic shaking."

In the absence of plate tectonic processes and water-caused erosion, the authors conclude that small impacts might be more important in shaping the Martian surface than previously thought.

"This is one part of a larger story about current surface activity on Mars, which we are realizing is very different than previously believed," said Alfred McEwen, principal investigator of the HiRISE project and one of the co-authors of the study. "We must understand how Mars works today before we can correctly interpret what may have happened when the climate was different, and before we can draw comparisons to Earth."

###

University of Arizona: http://uanews.org

Thanks to University of Arizona for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 76 time(s).

Source: http://www.labspaces.net/116106/Meteorite_shockwaves_trigger_dust_avalanches_on_Mars

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Spring Dekaney head coach Willie Amendola is upended as an out of control cart runs several bystanders over on the Cowboys Stadium field after Spring Dekaney defeated Cibolo Steele 34-14 during the Class 5A Divison II state championships high school football game on Saturday, Dec. 17, 2011, in Arlington, Texas. Two people were taken off the field by stretcher. (AP Photo/The Courier, Patric Schneider)

ARLINGTON, Texas (AP) ? A runaway electric cart raced unmanned from an end zone to midfield at Cowboys Stadium and plowed into several people after a high school championship game Saturday night, bowling over the winning head coach and several others.

An emergency medical technician who declined identification told The Associated Press that one man who was conscious and talking was taken to a hospital with an apparent leg injury. The Arlington medical technician said he had no further information on the man's condition but several others hit or grazed by the cart were checked out by emergency workers as they sprawled stunned on the field.

Separately, a Texas sports league official said a male staffer also was injured, not seriously, when the cart raced across field in a matter of seconds during onfield celebrations after the Texas 5A Division II football championship game. That official also declined identification.

The cart toppled Spring Dekaney coach Willie Amendola, who was being interviewed near the Cowboys midfield star, along with several others clustered about him moments after Dekaney had beaten Cibolo Steele 34-14. Hundreds of people were scattered about the field or were in the stands at the time.

Broadcast footage showed a stunned Amendola falling backwards into the cart's passenger seat as it continued rolling. He appeared to try unsuccesfully to gain control of the cart, spinning the steering wheel with his left hand, before rolling out onto the artificial turf. As he tumbled out, a pursuing field worker hopped aboard and stopped the cart quickly.

"We have a disturbance down the field. Apparently one of the carts on the field got loose and I think there have been some folks injured in this. Oh my! That's like a runaway cart there. And it finally took someone to stop it," a shaken announcer is heard commenting on air as the cart rolled and then stopped. "That's a scary thing."

Others were seen on the ground afterward as emergency personnel rushed up, including one man sprawled motionless while someone cradled his head. Nearby, others helped a visibly stunned man to his feet.

It was unclear why or how the cart began moving under its own power. Stadium workers were picking up fluorescent orange sideline yard markers and pylons in one of the end zones after the game when the cart unexpectedly took off.

During its race across the field, the cart appeared to roll over the legs of some of those onfield. Afterward, televised broadcasts showed Amendola conducting another interview with a small streak of blood on his left forearm.

An Arlington police dispatcher as well as a spokeswoman for Texas Health Arlington Memorial Hospital, where at least one injured person was reported taken, told AP they had no information to release early Sunday.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2011-12-18-US-Cowboys-Stadium-Runaway-Cart/id-db56f665d9ec49c8b789d3806124d0b2

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PARIS (Reuters) ? France's telecoms regulator has received bids from all four of the country's major operators for fourth-generation wireless licenses and will choose the winners of the auction in the coming weeks.

ARCEP said in a statement on Thursday that France Telecom, SFR, Bouygues and Iliad had submitted offers in the second round of bidding for the 4G mobile licenses.

It did not disclose how much each company had bid. But the French government aims to raise at least 1.8 billion euros ($2.33 billion) from the second round of the auction in which the best-quality frequencies are being sold in the 800 MHz band.

France has already sold off a batch of frequencies in the 2.6 GHz band for 936 million euros.

In the first round, France Telecom and soon-to-be new mobile player Iliad won the two larger blocks of 20 megahertz, while SFR and Bouygues got 15 MHz each.

The results of the auction will shape the competitive landscape in France's telecom market for years to come. The amount of spectrum an operator has determines the quality of service it can offer customers surfing the web from smartphones or tablets, a lucrative and fast-growing market.

($1 = 0.7721 euros)

(Reporting by Leila Abboud; Editing by James Regan)

Source: http://us.rd.yahoo.com/dailynews/rss/europe/*http%3A//news.yahoo.com/s/nm/20111215/tc_nm/us_francetel

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Researchers describe a new genetic program that converts static cells into mobile invasive cells

Thursday, December 15, 2011

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have identified the gene GATA 6 as responsible for epithelial cells -which group together and are static- losing adhesion and moving towards a new site. This process, which is common to developing organisms, is very similar to one that occurs in metastasis, when tumour cells escape from the original tumour and invade new tissue. "This process explains why Gata 6 is found in cancers of the liver, pancreas and colon, thus allowing tumour cells to acquire metastatic properties", stresses Jordi Casanova, CSIC professor and head of the Drosophila Morphogenesis Group at IRB Barcelona, where the study has been conducted. The journal Developmental Cell is to publish the results of this study this week.

In addition, Gata 6 triggers a genetic programme that favours the survival and adaptation of cells in new tissue. It also promotes the expression of some enzymes, the so-called metalloproteases, which degrade the cellular matrix, thus allowing cells to migrate and enter new tissue. Furthermore, Gata 6 induces the gene Forkhead, which is a survival factor. "When cells start migrating they are subjected to many changes and to stress, and in these adverse conditions many can die. This gene protects them against death", explains Kira Campbell, "Juan de la Cierva" post-doctoral fellow with Casanova's lab and first author of the article. Tumour cells hold metalloproteases and Forkhead.

From the Drosophila fly to cancer

Once again the small fly D. melanogaster, used in developmental studies, has shed light on processes linked to cancer. Casanova's team, which specializes in morphogenesis, has revealed the mechanism by which epithelial cells transform into mesenchymatic cells during gut development in fly embryos. The Drosophila gut is an endodermal organ, as is the colon, the liver and the pancreas. "What we have discovered is that the programme that we have characterized for the first time is specific for endodermal tissues", explains Casanova.

Having identified the genetic programme that favours this transformation in Drosophila, Casanova contacted Eduard Batlle's lab, which focuses on colorectal cancer and is also at IRB Barcelona. The aim was to test whether the homologue gene in mammal cells had the capacity to produce this same change. Their studies showed that this gene homologue, GATA 6, is conserved and confers cells the same capacities as those observed in the fly. "We started off with a strictly basic research line in development and have ended up with a collaboration with the Oncology Programme to address possible implications in cancer", says Casanova, emphasizing the multidisciplinary nature of the study. His lab now wishes to turn its attention to other members of the GATA family. "For example, pancreatic cancer has very poor prognosis. Our research can contribute to furthering understanding of the genetic bases of endodermal tumours and may speed up the detection of possible therapeutic targets".

###

Institute for Research in Biomedicine (IRB Barcelona): http://www.irbbarcelona.org

Thanks to Institute for Research in Biomedicine (IRB Barcelona) for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 46 time(s).

Source: http://www.labspaces.net/116058/Researchers_describe_a_new_genetic_program_that_converts_static_cells_into_mobile_invasive_cells

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Qualcomm's Gobi 3000 is already a big hit around these parts for its dual-mode CDMA and GSM radios, which makes staying connected much easier for serious globe trotters. Its no surprise then that HP chose that particular chip for its DataPass-enabled laptops which offer pay-as-you-go mobile broadband. For those that only need occasional access to 3G on the go or who cant stay in one country for more than a few weeks at a time DataPass and the flexible Gobi radio are a perfect match. Check out the PR after the break for a bit more of Qualcomm's gloating.

Continue reading Qualcomm's Gobi 3000 finds a home in HP laptops, delivers standard agnostic DataPass

Qualcomm's Gobi 3000 finds a home in HP laptops, delivers standard agnostic DataPass originally appeared on Engadget on Fri, 16 Dec 2011 07:21:00 EDT. Please see our terms for use of feeds.

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BEIJING (Reuters) ? Hollywood actor Christian Bale was roughed up by Chinese security guards as he attempted to visit a blind legal activist whose detention has sparked a domestic and international outcry, CNN reported on Friday.

Bale, who plays crime-fighting superhero Batman, and the camera crew from CNN were jostled by men in plainclothes from Dongshigu village in eastern Shandong province, where activist Chen Guangcheng has been under house arrest for 15 months, according to a video released by CNN on its website.

"Why can I not visit this man?" Bale asked several security officers, while they were pushing him.

"You know, I'm not being brave doing this," Bale told CNN. "The local people who are standing up to the authorities and insisting on going to visit Chen and his family and getting beaten up for it, and my understanding, getting detained for it and everything. I want to support what they are doing."

CNN said the guards shadowed its van for more than half an hour.

The fate of Chen, a self-schooled advocate who has campaigned against forced abortions, has become a test of wills, pitting the Communist Party's crackdown on dissent against activists championing his cause and that of artist Ai Weiwei.

In recent months, dozens of supporters have been blocked from visiting Chen. Many were beaten by men in plain clothes.

CNN said that Bale, who is in China for the premiere of his latest film "The Flowers of War," approached the news network to try to meet Chen. They took an eight-hour car journey to Chen's village from Beijing.

"This doesn't come naturally to me," Bale said to CNN. "But this was just a situation, I said, I can't look the other way."

Internet users took to the Twitter-like microblogging service, Weibo, to applaud Bale's visit to see the "blind man." Aauthorities have blocked searches for "Chen Guangcheng."

"Mr. Bale, I admire your courage and heart," said a microblogger called "Chen Xiaoying wants to support."

"But next time if you want to save a person, remember to wear your Batman suit.The Chinese official media will not report this, it's up to CNN to broadcast it."

Chen angered Shandong officials in 2005 by exposing a program of forced abortions as part of China's one-child policy. He was formally released in September 2010 after four years in jail on a charge of "blocking traffic."

"What I really wanted to do is to shake the man's hand and say: 'Thank you,' and tell him what an inspiration he is," Bale told CNN.

(Reporting by Sui-Lee Wee, Additional reporting by Beijing Newsroom,; Editing by Ken Wills and Ron Popeski)

Source: http://us.rd.yahoo.com/dailynews/rss/movies/*http%3A//news.yahoo.com/s/nm/20111216/en_nm/us_china_bale_activist

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DURBAN, South Africa (Reuters) ? Cash raised by the shipping industry's efforts to cut carbon emissions might be directed to developing countries to help them tackle climate change, a draft document seen by Reuters showed at United Nations climate talks on Tuesday.

The text proposes that money raised by "specific actions" to reduce emissions from maritime bunker fuels, which may be designed and implemented by the International Maritime Organization (IMO), could be distributed to developing countries and used to finance climate adaptation through a Green Climate Fund.

Negotiators will discuss the proposal later on Tuesday.

Several delegates at a U.N. climate summit in Durban doubted there would be agreement on the proposal. They said any final deal at the end of the week would be worded vaguely.

"I don't expect any clear outcome but if something stays in the text, it would be a big step in a small way," said Bas Eickhout, European Member of Parliament.

"Everything boils down to where is the money? I think that the entire financial decision is going to be a big deal in Rio," he added, referring to a U.N. conference on sustainable development in June next year.

Nearly 200 countries are meeting in Durban until December 9 at a United Nations summit to try to hammer out a new global climate treaty.

The United Nations hopes delegates attending the global climate talks will agree on the design of the Green Climate Fund, which aims to channel up to $100 billion a year by 2020 to countries most at risk from the effects of climate change, such as rising sea levels and temperatures and crop failure.

Concrete progress on funding would help revive the flagging talks, hampered by rifts between countries on the form of a new global pact.

VAGUE

This is the first time a concrete source of funding has been raised in a U.N. text, but Tuesday's draft did not define whether revenues would be raised by a levy.

Last month, campaign groups Oxfam and WWF urged a carbon price of $25 per metric ton should be applied to shipping fuel (known as bunker fuel) to help cut emissions and generate $25 billion a year by 2020.

They suggested the revenues raised should be used to compensate developing countries for slightly higher import costs resulting from a carbon price, and to provide more than $10 billion per year for the Green Climate Fund.

"The text is vague on the details of implementation .. If it's a levy, it could be collected directly from ships, or it could be collected from bunker fuel suppliers," said Tim Gore, policy advisor at Oxfam.

"If it's an emissions trading scheme, there could be a common auctioning platform, or each country could auction (carbon) allowances. All such details would be resolved subsequently in the IMO, if this text were agreed," he added.

International shipping accounts for around 3.3 percent of the world's man-made carbon dioxide emissions and could grow by 150 to 250 percent by 2050 if regulation is not in place.

The IMO has made little progress in implementing market-based mechanisms to control the sector's emissions, even though the EU Commission has threatened to include it in its carbon market.

In July, the IMO managed to agree on energy efficiency design standards for new ships to cut emissions, but developing countries can delay implementation by using a waiver.

(Additional reporting by Andrew Allan, Barbara Lewis and Michael Szabo; Editing by William Hardy)

Source: http://us.rd.yahoo.com/dailynews/rss/environment/*http%3A//news.yahoo.com/s/nm/20111206/wl_nm/us_climate_maritime

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JAKARTA, Indonesia ? Police say a senior executive of Canada's Research In Motion is a suspect in last month's stampede at a BlackBerry promotion in Indonesia.

Police spokesman Col. Baharudin Djafar said Monday that several people fainted and dozens were injured at the global debut of the BlackBerry Bold 9790.

The $540 phones ? commonly known as Bellagios ? were being sold at half price to the first 1,000 shoppers.

Djafar said Canadian Andy Cobham, the outgoing country director for RIM, is among four suspects who could face charges of negligence leading to injury.

The crime carries a maximum penalty of nine months in prison.

Indonesia, a nation of 240 million people, has experienced a come-from-nowhere tech frenzy in recent years. With 6 million users, BlackBerry is more popular in Indonesia that smartphones from other makers.

Source: http://us.rd.yahoo.com/dailynews/rss/personaltech/*http%3A//news.yahoo.com/s/ap/20111205/ap_on_hi_te/as_indonesia_canada_blackberry

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John Schults / Reuters

France's President Nicolas Sarkozy (L) greets German Chancellor Angela Merkel before a working lunch at the Elysee Palace in Paris December 5, 2011.

By John W. Schoen, Senior Producer

The latest plan to save Europe calls for the boldest moves yet to save the euro zone from financial collapse. Despite that looming threat, though, Europe's leaders, and their voters back home, remain deeply split over the same issues that that have doomed a series of failed proposals over the last two years.?

The latest plan calls for a new treaty that would fix one of the most critical, longstanding flaws in Europe?s monetary union: the lack of centralized control over member countries' decisions about taxes and spending. The absence of those controls have allowed free spending nations like Greece and Italy to run up massive national debts that larger countries, like France and Germany, have refused to backstop.

The new treaty, requiring approval by all 17 countries that use the euro, would include automatic sanctions for countries that fail to keep government deficits in check.

For now, the latest proposal has given European bankers and political leaders some breathing room, as investors gave the idea a vote of confidence. Following the announcement Monday, the euro rose against the dollar, stocks gained and yields on European government bonds dropped.

?The fiscal stick is being rewarded by the market carrot,? said Douglas Borthwick, a currency trader with Faros Trading. ?We continue to expect this going forward. The market rewards fiscal responsibility.?

But the markets have rallied?on hopeful pronouncements from the leaders of Europe's "core?countries? before, only to have those?proposals?dead-ended by the?complex?political process of forging consensus among 17 countries whose voters are leery of ceding their national independence to a centralized spending authority in Brussels. European leaders are scheduled to consider the latest proposals at a summit in Brussels Dec. 9.

As with past failed proposals, the latest?announcement?came from French president Nicolas Sarkozy and German Chancellor Angela Merkel, the two strongest ?core? economies that are struggling to stem the contagion from the weaker, heavily-indebted peripheral?economies of Greece, Italy, Spain, Portugal and Ireland.

Despite that common interest, the two countries remain divided over key elements of any bailout plan.

?There are still significant differences between Sarkozy and Merkel, so we're in for a volatile week,? said Patrice Perois, a trader at Kepler Capital Markets. ?The risk is that any kind of disappointment could trigger a (market) pull-back."

France has long opposed efforts to dilute its national independence by turning over control of budgetary decisions to a central European agency with the power to veto spending decisions. Various enforcement mechanisms have been considered, including granting the European Court of Justice the power to punish governments that defy centrally-imposed spending limits. Just months away from a presidential election, Sarkozy faces rivals warning voters that he is prepared to sacrifice French sovereignty to unelected EU officials.

For their part, German voters are loathe to allow their taxes to be spent bailing out weaker, free-spending countries. Faced with German voter?s deep-seated fears of a recurrence of the 1920?s hyperinflation that sank the Weimar Republic, Merkel has also staunchly opposed the idea of letting the European Central Bank print euros to underwrite massive bond purchases, ?

The long-simmering crisis reached a boiling point in the past few weeks as investors became increasingly skeptical about a series of broken promises to get Europe?s fiscal house in order. Those investors have demand higher interest rates on European government debt to offset the risk they won?t get their money back.

The euro is holding firm against the dollar, boosted by optimism on Italian austerity measures and the Merkel-Sarkozy meeting, with Marc Chandler, Brown Brothers Harriman.

Europe?s weaker countries, including Greece, Portugal and Spain, have been paying that premium for months as budget-balancing spending cuts sapped economic growth and cut into revenues, which forced deeper cuts in a downward economic spiral. ?European leaders have assembled a collection of war chests to bail out those countries if they reach the end of their fiscal rope.

The crisis entered a new phase last month, when the rate on Italian bonds soared to 8 percent, a level widely acknowledged as unsustainable. With the third largest pool of debt, behind the U.S. and Japan, Italy?s debt load is far too big to bail out. Various proposals to find bigger pools of bailout funding, including a proposal that the European Central Bank simply print more euros, have run into?political, technical and legal roadblocks.

The latest round of proposals also includes a bid to raise Europe?s member country contributions to the International Monetary Fund, which would expand its financial firepower to backstop a debt default. The IMF so far has failed to attract larger contributions from countries outside Europe, including the U.S., China and Brazil.

?

Source: http://bottomline.msnbc.msn.com/_news/2011/12/05/9225158-europe-has-new-debt-plan-and-lots-of-familiar-obstacles

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